EndNote Click helps researchers access and use journal articles across academic websites. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023 Part 1 (Regular and Invited Abstracts) 2023 Apr 14-19 Orlando, FL. Description The official EndNote browser extension. Blockade of the cyclooxygenase-2 prevents chemotherapy-induced cognitive impairments.
Tang, Ki-Hyun Yoo, Ana Corujo-Ramirez, Sang Hoon Kim, Alfredo Oliveros, Peter Cole, John R. Given that COX-2 inhibitors are currently being tested in cancer prevention as well as age-related memory loss in clinical trials, inhibiting COX-2 may have far-reaching therapeutic effects on CICI and cancer treatment, which can be applied quickly, safely, and effectively to clinical trials, in the effort to improve cancer survivor quality of life.Ĭitation Format: Mohammad Abdur Rashid, Jason J. Taken together, our findings strongly suggest that COX-2 induction is a main cause of CICI, making COX-2 inhibition a therapeutic target for CICI. Most importantly, NS-398, a selective COX-2 inhibitor, effectively prevents cognitive deficits in mice and reduction in cell viability of human neurons associated with these chemotherapies, without promoting tumor growth or interfering with cisplatin’s anti-tumor activity.
Similar as cisplatin treatment, the levels of COX-2 expression began to increase at 0.1 µM methotrexate treatment, which significantly increased at 1 µM in human cortical neurons, indicating that COX-2 induction is a common pathogenic mechanism mediating cognitive impairment associated with cisplatin and methotrexate in spite of the fact that these compounds have different mechanisms of action for cancer eradication. Mechanistically, our RNA-sequencing and qRT-PCR analysis revealed that cisplatin dramatically increases COX-2 (Ptgs2) expression and its major product, prostaglandin E 2 (PGE 2) in adult mouse brain and human cortical neurons derived from induced pluripotent stem cells (iPSCs). We further show that cisplatin causes oxidative DNA damage, mitochondrial defects, impaired neurogenesis, synaptic defects, and increased gliosis in the adult hippocampus, a brain region critical for learning and memory. Utilizing cisplatin, a platinum-based chemotherapy, to model chemobrain mice in vivo, we have established that cisplatin accelerates the brain aging process thus leading to long-term memory impairment in mice similar to what is clinically reported. Unfortunately, there is no treatment and novel therapies are urgently needed. More importantly, CICI persists well after cessation of therapy, severely interfering with quality of life. These side effects affect approximately 14 million cancer survivors. Users can synchronize their EndNote library across desktop, iPad and online platforms.Chemotherapy-induced cognitive impairment (CICI, also termed “chemobrain”) is a major neurotoxic side effect exhibited by a wide range of chemotherapeutic agents. Starting with EndNote X7, users can share a library among 15 people.ĮndNote has three plaftforms: EndNote desktop program with online access (EndNote desktop), a cloud-based version of EndNote with online access only (often known as EndNote basic, EndNote online, or EndNote Web), and EndNote for iPad. This blog was designed to help our patrons in the use of EndNote and provide updates and news about EndNote.ĮndNote is a bibliographic management tool, allowing users to collect and organize references from databases and other sources, create a searchable personal database, find and cite these references while writing, and create bibliographies formatted in their style of choice. Welcome to the Rutgers Users’ EndNote Blog.
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